The next generation bone substitute mixable with antibiotic
The next generation bone substitute mixable with antibiotic
A LOCAL AND SUSTAINED ANTIBIOTIC
RELEASING BONE SUBSTITUTE
BIOCERA-VET® BONE SURGERY COMBO-CLEAN features ideal properties of a bone substitute with local and sustained antibiotic delivery. Its high porosity allows an optimal osteointegration and promotes bone remodelling, provides stability along with antimicrobial action for up to 30 days*.
BIOCERA-VET Combo-Clean is made of tricalcium phosphate (α-TCP) and ortho-phosphate salts to which an antibiotic is added and that gives rise to calcium-deficient apatite after crystallization.
After crystallization, BIOCERA-VET Combo-Clean presents a high porosity (micro-, meso- and macro- pores) which supports bone remodeling through cell colonization and biological fluid penetration, and at the same time allows the paced release of antibiotic over time and its effect on local infection.
*antimicrobial activity depends on the antibiotic & can reach up to 30 days above the MIC for the gentamicin, cefazolin and amoxicillin (MIC of S.aureus (or S. Agalactae for amoxicillin) and E.Coli)
GET OUR BONE SURGERY COMBO-CLEAN PRODUCTS
WHY BIOCERA-VET BONE SURGERY COMBO-CLEAN?
Fast-setting and mechanical strength
Excellent osteointegration
Accelerated bone consolidation
Sustained antimicrobial activity
ANTIMICROBIAL ACTION COVERING ALL THE COMMON BACTERIA INVOLVED IN BONE INFECTION
The 7 antibiotics suitable for BIOCERA-VET Combo-Clean cover all the most frequent Gram + (9 bacterial species) and Gram – (9 bacterial species) responsible for bone infection. Gram + : S. Pseudointermedius, S. Aureus, Streptococcus sp., Enterococcus sp., Corynebacterium sp., Clostridium sp., Actinomyces sp., Propionibacterium sp., Peptostreptococcus sp. Gram – : Bacteroides sp., Fusobacterium sp., E. coli, P. aeruginosa, Enterobacter sp., Pasteurella sp., Klebsiella sp., Serratia sp., Proteus sp.
“BIOCERA-VET BONE SURGERY COMBO CLEAN was easy to mix with Gentamicin, injection at the surgical site was good allowing to provide a local and prolonged treatment with antibiotics. This resulted in a satisfactory new bone formation of an infected surgical site. “
Dr. Inge Comeyne, DVM, Orthopedic Surgeon (Belgium)
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